Dr Simon Chu completed his PhD at Hudson Institute of Medical Research in 2005. His studies focused on the roles of oestrogen receptors in the pathogenesis of ovarian granulosa cell tumours (GCT), an uncommon type of ovarian cancer. In particular, he identified how estrogen receptor signalling was affected by other important molecular signalling pathways. This led to discovering a role for another important protein (the X-linked inhibitor of Apoptosis Protein), that contributes to the pathogenesis of not only GCT, but also for the more common epithelial ovarian cancers (EOC). After gaining his PhD, Dr Chu continued his work at the Hudson Institute of Medical Research, further examining these important pathways with the aim of identifying new therapeutic targets to treat both GCT and EOC.
In 2007, Dr Chu left the Hudson Institute of Medical Research to take up a postdoctoral position at the Pasteur Institute (Cambodia Campus), where he began training as a molecular virologist, and helped develop a new molecular technique to investigate the incidence of exposure to avian influenza in the human population in that country.
On his return to Australia in April 2009, Dr Chu returned to the Hudson Institute of Medical Research as an OCRF Research Fellow. His work now focuses on investigating the underlying causes of both EOC and GCT. He is currently investigating an exciting potential combined therapeutic option for treating these cancers, which target two important biological pathways in the ovarian cancer cell. This presents a new targeted therapeutic approach for the treatment of ovarian cancer.
Project: (1) Efficacy of Smac Mimetics to treat Epithelial Ovarian Cancer and Granulosa Cell Tumours (2) The role of the FOXL2 C134W mutation in Granulosa Cell Tumours